Symposium Speaker

Michel B. Toledano

Michel B. Toledano is a Research Director and currently chief of the Oxidative Stress and Cancer Laboratory (LSOC). He received his M.D. in 1988, and is Ph.D. in 1993 from the Paris VII University.

Dr. Toledano is a molecular biologist with an expertise in oxidative stress and redox regulation. He was one of the first to show that proteins can be regulated by reversible cysteine oxidation, and proposed several mechanisms for this type of regulation. He first showed that a mammalian transcription factor, NF-B, can be regulated by reversible cysteine oxidation (PNAS, 1991), and then that oxidation of the E. coli H₂O₂ response regulator OxyR changes its DNA binding specificity, allowing it to activate different promoters when reduced or oxidized (Cell, 1994). He showed that the S. cerevisiae H₂O₂ stress regulator Yap1 is activated by reversible oxidation (EMBO J, 2000), through a mechanism involving a thiol-peroxidase that senses H2O2, a new concept in redox biology (Cell, 2002). He discovered a new redox enzyme, sulfiredoxin, which catalyzes a hitherto unknown reaction, the reduction of the cysteine sulfinic acid form (Nature, 2003). He has proposed a novel model for the eukaryotic glutathione and thioredoxin pathways, showing how these pathways are split between thiol-redox control and iron metabolism (EMBO J., 2011). He also pioneered redox proteomic strategies.

Dr Toledano is an author or co-author of 57 peer reviewed scientific articles (h factor = 28). He has received the “Grand Prix of Molecular Biology Jules Martin” from the French National Academy of Science. He has teaching academic and science evaluation duties. He is regularly invited to present his work at scientific meetings.

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