HNE 2012 Club Satellite Meeting Invited Speaker

Dennis Petersen

Dennis Petersen is Professor of Pharmacogenetics and Pharmacology in the Department of Pharmaceutical Sciences at the University of Colorado School of Pharmacy, Aurora, Colorado. He obtained his BSc in Animal Science from Sul Ross State University and his PhD in Biochemical Genetics from the University of Wyoming. The primary focus of research in Dr. Petersen’s laboratory involves understanding the molecular mechanisms of oxidative stress as it relates to initiation and progression of liver injury. The biotransformation of ethanol, as well as liver disorders associated with the accumulation of lipid, result in oxidative stress leading to the peroxidation of membrane lipids. Products of this lipid peroxidative process include chemically reactive aldehydes that that have the potential to modify proteins involved in critical metabolic pathways or signaling cascades. A central goal of our studies is to identify the cellular proteins which are targets for by these biogenic aldehydes in order to understand how and why they are selectively modified and also determine the cellular consequences of the modification. Currently, his laboratory is employing immunologic procedures and mass spectrometry to isolate and identify the aldehyde-modified proteins from cellular or animal models subjected to various forms of oxidative stress. Further information is available from: ucdenver.edu

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