Full Professor of Nutritional Toxicology at Friedrich Schiller University Jena.
Studies of Medical Biochemistry in Moscow, Russia, Graduation at the Humboldt University Berlin (Charité), Germany, followed by post-doc positions in Berlin, Germany, and Albany (NY), US, several faculty positions in Berlin, Germany, and Düsseldorf, Germany, and full professorship at the University of Hohenheim, Stuttgart, Germany.
Editor for Free Radic. Res., and on the Editorial Board of several journals, including Free Radic. Biol. Med., Mol Asp. Med..
Chairman of the European COST network CM1001 on 'Nonenzymatic posttranslational protein modification' and vice-chair of the European project MARK-AGE on 'Biomarkers of Aging' Publications >250, h-Index 36.
The research is focused on the oxidative stress response of cells. The oxidative damage to proteins, the protection of proteins from oxidation and the fate of a protein if it is oxidized are major research topics. Therefore, various proteases and proteolytic systems for the ability to recognize and degrade oxidized proteins are investigated.
Recently we focus on oxidation-related changes in the aging process. Model systems of aging skin or brain are employed to investigate processes of lipid peroxidation, protein oxidation, the removal of oxidized protein and effects of nutritional components on these processes. A central role in these investigations is the investigation of functional consequences of the formed age-related protein aggregates.
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