International Scientific Program Committee
Howard J. Halpern
NAME
Halpern, Howard J.		 POSITION TITLE
Professor
eRA COMMONS USER NAME (credential, e.g., agency login)
HHALPERN
INSTITUTION AND LOCATION DEGREE MM/YY FIELD OF STUDY
Harvard University A.B. 1967 Physics
University of Wisconsin, Madison, WI Ph.D. 1976 Physics (High Energy)
University of Miami School of Medicine M.D. 1980 Medicine
Harvard/Joint Center for Radiation Therapy Resident 1984 Radiation Oncology

A. Personal Statement

Dr. Halpern spends a large fraction of his time as the Director (PI) of the NIH Center for EPR Imaging In Vivo Physiology and as PI of an NIH research grant exploring application of the technology developed in the Center. A major focus of this research effort is to develop high resolution noninvasive images of oxygen distributions in tumors and normal tissues living animals. The Center has already scaled images to rat and rabbit tumors that approach the size of human tumors. Eventual human tumor imaging is anticipated.
Dr. Halpern is both a physicist, supporting graduate students as a member of the Committee of Medical Physics and a physician training Radiation Oncology residents. There are many applications of EPR oxygen images (EPROI) to tumor physiology that instruct different aspects of the tumor micro-environment, this particular work is of particular importance. There are a number of applications of EPROI to stroke, MI and peripheral vascular disease but the initiating impulse behind the development of the center has been the application to evaluation of solid tumors for radiation therapy and the exploration of EPROI for application to dose painting in patients.


B. Positions and Honors

1973-1977 Research Associate, Department of Physics, Carnegie-Mellon University, Pittsburg, PA
1977-1978 Postdoctoral Research Associate, Division of High Energy Physics, Argonne National Laboratory, Argonne, IL.
1982-1985 Instructor, Radiation Therapy, Harvard Medical School, Boston, MA
1985-Present Staff Member, Franklin McLean Memorial Research Institute, University of Chicago, Chicago, IL
1985-1993 Assistant Professor, Michael Reese/University of Chicago Center for Radiation Therapy, Dept. of Radiation Oncology, University of Chicago, Chicago, IL
1993-1997 Associate Professor, Michael Reese/University of Chicago Center for Radiation Therapy, Dept. of Radiation Oncology, University of Chicago, Chicago, IL
1997-Present Professor, Department of Radiation Oncology, University of Chicago, Chicago, IL
1999-Present Director, NIH (NIBIB) Center for EPR Imaging In Vivo Physiology


C. Selected Peer-reviewed Publications (Selected from 117 peer-reviewed publications)
  1. Halpern HJ, Bowman MK, Spencer DP, Van Polen J, Dowey EM, Massoth RJ, Nelson AC, Teicher BA: An imaging radiofrequency electron spin resonance spectrometer with high resolution and sensitivity for in vivo measurements. Rev. Sci. Instr. 60:1040-1050, 1989.
  2. Halpern H.J. Yu C. Peric M. Barth E. Bowman M.K. Grdina D. Teicher B.A.: Oxymetry deep in tissues with low frequency electron paramagnetic resonance. Proc. Natl. Acad. Sci. USA 91:13047-13051, 1994. PMCID: PMC45578
  3. Halpern H.J. Yu C. Barth E. Peric M. Rosen G.M.: In Situ detection of hydroxyl radical markers by spin trapping produced from ionizing radiation in the tumor of a liviing mouse. Proc. Natl. Acad. Sci. USA. 92:796-800, 1995. PMCID: PMC42707
  4. Heimann R, Powers C, Halpern HJ, Michel A, Ewing C, Wyman B, Recant W, Weichselbaum R: Breast preservation in stage I and II carcinoma of the breast: the University of Chicago Experience. Cancer 78:1722-1730, 1996.
  5. Halpern H.J. Chandramouli G.V.R. Barth E.D. Yu C. et al. Diminished aqueous microvisosity of tumors in murine models measured with in vivo radiofrequency EPR. Cancer Research. 59:5836-41, 1999. PMID: 10582707
  6. Iwama T, Reddy TJ, Halpern HJ, Rawal VH. General synthesis of persistent trityl radicals for EPR imaging of biological systems. J. Org. Chem. 67:4635-4639, 2002. PMID: 12098269
  7. Elas M, Williams BB, Parasca A … ,Halpern HJ. Quantitative Tumor Oxymetric Images from 4-Dimensional Electron Paramagnetic Resonance Imaging (EPRI): Methodology and Comparison with Blood Oxygen Level Dependent (BOLD) MRI. Magn. Reson. Med. :49:682-91,2003. PMID: 12652539
  8. Mailer C, Robinson BH, Halpern, HJ. Spectral Fitting: The extraction of crucial information from a spectrum and a spectral image. Magn. Reson. Med. 49:1175-1180, 2003. PMID: 12768598
  9. Carson PL, Giger M, Welch MJ, Halpern H, Kurdziel K, Vannier M, Evelhoch JL, Gazelle GS, Seltzer SE, Judy P, Hendee WR, Bourland JD. Biomedical imaging research opportunities workshop: report and recommendations. Radiology: 229:328-339, 2003.
  10. Mailer C, Subramanian VS, Pelizzari CA and Halpern HJ. Spin echo spectroscopic EPR imaging. Magn. Reson. Med. 55, 904-12, 2006. PMID: 16526015
  11. Elas M, Ahn K-H,Parasca A, Barth ED, Lee D, Haney C, Halpern HJ. Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with OxyliteTM oxygen measurements. Clin. Ca. Res.12: 4209-4217, 2006. PMID: 16857793
  12. Elas M, Bell R,Hleihel D,...Halpern HJ. Electron paramagnetic resonance (EPR) oxygen image hypoxic fraction plus radiation dose predict tumor cure in FSA fibrosarcomas. Int. J. Radiat. Oncol. Biol. Phys 7,542-9, 2008. PMCID: PMC2577780
  13. Epel B, Sundramoorthy SV, Mailer C, Halpern HJ. A versatile high speed 250-MHz pulse imager for biomedical applications. Concepts in Magnetic Resonance Part B-Magnetic Resonance Engineering 33B,163-176, 2008;
  14. Haney CR , Parasca AD, Fan X, Bell R, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ, Weichselbaum RR and Pelizzari CA,. Characterization of Response to Radiation Mediated Gene Therapy via Multi-Modality Imaging. Magn. Reson. Med.62, 348-56, 2009
  15. Epel B, Hleihel D, Barth ED, Haney CR Halpern HJ. Electron Paramagnetic Resonance Imaging of a Rabbit using Localized Spin Probe Delivery. Med. Phys.37:2553-2559, 2010
  16. Elas M, Hleihel D, Barth ED, Haney CR, Ahn K-H, Pelizzari CA,, Epel B, Kocherginsky M, Weichselbaum RR, Halpern HJ. Where Its At Really Matters: In Situ In Vivo Vascular Endothelial Growth Factor Spatially Correlates with Electron Paramagnetic Resonance pO2 Images in Tumors of Living Mice. Mol. Imaging Biol. 13: 1107-13, 2011PMID: 20960236
  17. Elas M, Ichikawa K, Halpern HJ. Oxidative stress imaging in live animals with techniques based on Electron Paramagnetic Resonance. Rad. Res. 177:514-23, 2012.
  18. Elas M, Magwood JM, Butler B,Li C,Wardak R, Barth ED, Epel B, Rubinstein S, Pelizzari CA, Weichselbaum RR and Halpern HJ. Electron paramagnetic resonance oxygen imaging predicts tumor control after a single 50 percent tumor control radiation dose. E-pub in Ca. Res 2013
  19. Epel B, Bowman MK, Mailer C, Halpern, HJ. Absolute Oxygen Imaging In Vivo with Pulse Electron Paramagnetic Resonance. Accepted for publication, Magn. Reson. Medicine 2013