Home REGISTRATION/INFORMATION DESK
5:00 pm - 8:00 pm | Grand Ballroom Foyer
REGISTRATION/INFORMATION DESK
7:00 am - 6:30 pm | Grand Ballroom Foyer
PRE-MEETING WORKSHOPS (2)
Full Day Pre-Meeting Workshop
Fundamentals in Redox Biology | 8:15 am – 3:00 pm | GRAND BALLROOM A
Chairs: Ohara Augusto, Ph.D., University of São Paulo, Brazil and Jacek Zielonka, Ph.D., Medical College of Wisconsin, USA
The investigation of redox processes can elucidate disease mechanisms and reveal new therapeutic targets, justifying the increasing scientific interest in redox biology. This workshop targets graduate students, trainees and newcomers to the area. The speakers will discuss state-of-the-art concepts and approaches to provide an in-depth understanding of the bases and perspectives of redox biology.
8:15 am – 8:20 am | Welcome
8:20 am – 9:00 am
Oxidants, Free Radicals and Redox Reactions in Biology
Christine Winterbourn, Ph.D., University of Otago, New Zealand
9:00 am – 9:40 am
Measurement of Cellular Oxidants with Small Molecule Probes
Jacek Zielonka, Ph.D., Medical College of Wisconsin, USA
9:40 am – 10:20 am
Novel Molecular Tools for Redox Imaging and Metabolic Engineering
Vsevolod Belousov, Ph.D., D.Sc., M.M. Shemyakin - Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russia
10:20 am – 10:40 am | Break
10:40 am – 11:20 am
Overview of Oxidative Damage to Biomolecules
Barry Halliwell, Ph.D., National University of Singapore, Singapore
11:20 am – 12:00 pm
Measurements of Oxidative Damage in Biological Samples
Sayuri Miyamoto, Ph.D., University of São Paulo, Brazil
12:00 pm – 1:00 pm | Lunch
1:00 pm – 1:40 pm
Redox Biochemistry of Thiols
Madia Trujillo, Ph.D., Universidad de la República, Uruguay
1:40 pm – 2:20 pm
Thiol-Based Redox Signaling
Henry Jay Forman, Ph.D., University of Southern California, USA
2:20 pm – 3:00 pm
The Redox Code
Dean Jones, Ph.D., Emory University, USA
Half Day Pre-Meeting Workshop
Redox Systems Biology | 1:00 pm – 3:30 pm | BAYVIEW A
Chairs: Rick Domann, Ph.D., The University of Iowa, USA and Melissa Kemp, Ph.D., Georgia Institute of Technology, USA
Systems biology emerged as a discipline to study biology from a global perspective, through interactions of components that give rise to higher-order properties; it is now easier than ever to collect large-scale data at the genomic, proteomic, and metabolomic-wide levels. How do we analyze, integrate and model –omics data to gain insight in redox biology? This workshop will discuss a breadth of systems biology tools and applications to initiate discussion on the complexity of redox systems.
1:00 pm - 1:10 pm | Welcome
1:10 pm – 1:40 pm
Roles of Peroxiredoxins in ROS Responses; New Insight from Systems Approaches Combining Computational and Genetic Studies
Elizabeth Veal, Ph.D., University of Newcastle, UK
1:40 pm –2:10 pm
Painting the Cysteine Chapel: Chemical Tools for Biological Discovery and Beyond
Kate Carroll, Ph.D., The Scripps Research Institute, USA
2:10 pm – 2:25 pm | Break
2:25 pm – 2:55 pm
Computational Systems Analysis: What Can We Learn About Redox-based Mechanisms?
Melissa Kemp, Ph.D., Georgia Institute of Technology, USA
2:55 pm – 3:25 pm
Quantitative Metabolomics Approaches to Understanding Glucose and Amino Acid Metabolism
Jason Locasale, Ph.D., Duke University School of Medicine, USA
3:25 pm - 3:30 pm | Summary
ANNUAL MEETING BEGINS
OPENING SESSION | 5:00 pm - 7:10 pm | GRAND BALLROOM
5:00 pm – 5:10 pm
SFRBM & SFRRI Presidents' Welcome
Neil Hogg Ph.D., Medical College of Wisconsin, USA, SFRBM President and Rafael Radi, MD, Ph.D., Universidad de la República - Uruguay, Uruguay, SFRRI President
PLENARY SESSION
Biomarkers for Oxidative Stress, Translation of Chemical and Biological Research into the in vivo and Clinical Setting
Chairs: Ginger Lohr Milne, Ph.D., Vanderbilt University, USA and Henrik Poulsen, MD, Rigshospitalet, University Hospital Copenhagen, Denmark
Great progress has been made in the mechanistic understanding of oxidative stress, however the translation of this knowledge into revelation of the importance of oxidative stress in diseases, their diagnosis, prognosis and treatment is still in its infancy. This symposium addresses the present stage of translational research on oxidative stress.
5:10 pm – 5:40 pm
Comparison of Different Oxidative Stress Biomarkers in vivo
Maria Kadiiska, Ph.D., MD, NIEHS/NIH, USA
5:40 pm – 6:10 pm
Sterol Oxidation: Errors in Cholesterol Biosynthesis
Ned Porter, Ph.D. Vanderbilt University, USA
6:10 pm – 6:40 pm
Are There Free Radical Diseases?
Henrik Poulsen, MD, Rigshospitalet, University Hospital Copenhagen, Denmark
6:40 pm – 7:10 pm
SFRBM LIFETIME ACHIEVEMENT LECTURE | GRAND BALLROOM
Redox Biology – Questions for the Future from the Perspective of an Aging Free Radical
Henry Jay Forman, Ph.D., University of Southern California, USA
7:15 pm – 8:30 pm
WELCOME RECEPTION | ATRIUM
7:15 pm – 8:30 pm
TRAINEE RECEPTION | ATRIUM
9:00 pm – 10:00 pm
HOSPITALITY | GARDEN ROOM
REGISTRATION/INFORMATION DESK
7:00 am - 6:30 pm | Grand Ballroom Foyer
SUNRISE FREE RADICAL SCHOOL
Back to the Basics | 8:00 am – 9:00 am | GRAND BALLROOM A
Chairs: Marcie Cole, Ph.D.., University of Louisville, USA and Madia Trujillo, Ph.D., Universidad de la República - Uruguay, Uruguay
8:00 am – 8:30 am
Approaches for Evaluation of H2O2 Mediated Protein Oxidation and Thiol-Disulfide Exchange Reactions
Leslie Poole, Ph.D., Wake Forest School of Medicine, USA
8:30 am – 9:00 am
Hydrogen Peroxide as a Signaling Molecule
Fernando Antunes Ph.D., Faculdade de Ciencias da Universidade de Lisboa, Portugal
PLENARY SESSION 1
9:30 am - 12:00 pm | GRAND BALLROOM A
Pivotal Role of H2O2 in Redox Regulation of Signaling and Transcription
Chairs: Helmut Sies, MD, University of Düsseldorf, Germany and Enrique Cadenas, Ph.D., MD, University of Southern California, USA
H2O2 is utilized in metabolic regulation in ways similar to diffusible gases such as NO, CO, or H2S, and it is recognized as a fundamental transcription-independent signal, in line with Ca2+ and ATP. H2O2 has been identified as a suitable second messenger molecule. This session addresses the mechanisms that involve H2O2 in redox signaling, its targets, and the functional consequences of H2O2 signaling. Novel aspects of H2O2-mediated redox regulation of cell signaling and transcriptional pathways are covered in terms of a redox relay for H2O2 signaling, identification of mitochondrial sites producing H2O2 and involved in cell signaling, and significance of mitochondrial ketoacid dehydrogenases as sources of H2O2.
9:30 am – 10:00 am
Sites of Mitochondrial Hydrogen Peroxide Generation
Martin Brand, Ph.D., Buck Institute for Research on Aging, USA
10:00 am – 10:30 am
Mechanisms of Mitochondrial ROS Production and Their Role in Redox Signaling
Stefan Dröse, Ph.D., University Hospital Frankfurt, Germany
10:30 am – 11:00 am | Break
11:00 am – 11:30 am
Hydrogen Peroxide Release from Mitochondria in Regulating Metabolic Functions
Jan Riemer, Ph.D., University of Cologne, Germany
11:30 am - 12:00 pm
Thioredoxin Reductase 1 (TrxR1) Links Cellular Signaling Pathways Controlling Cellular Phenotype to H2O2 Modulation, Nitrosylation, and Persulfidation Pathways
Elias S. J. Arnér, MD, Ph.D., Karolinska Institutet, Sweden
PLENARY SESSION 2
9:30 am - 12:00 pm | GRAND BALLROOM B
Dual Role of Oxidants Generated by Leukocyte Enzymes in Health and Disease
Chairs: Clare Hawkins, Ph.D., Heart Research Institute, Australia and Michael Davies, Ph.D., Panum Institute, University of Copenhagen, Denmark
Leukocytes generate very high oxidant fluxes when subject to appropriate stimuli, with O2consumption rates being up to 2500-fold higher than for other cells. They are therefore “professional” oxidant generators. These oxidants are important for killing invading pathogens, but this comes at a major cost to the host in “collateral” damage, with host cells subject to severe oxidative damage. Such oxidative host tissue damage has been associated with many diseases. Thus oxidation induced by leukocyte enzymes has both positive and negative effects, and understanding these mechanisms and their control, is critically important in physiological and pathological situations.
9:30 am – 10:00 am
Positives and Negatives of Oxidant Formation by Neutrophils
Christine Winterbourn, Ph.D., University of Otago, New Zealand
10:00 am – 10:30 am
Neutrophil Extracellular Traps
Arturo Zychlinsky, Ph.D., Max Planck Institute for Infection Biology, Germany
10:30 am – 11:00 am | Break
11:00 am – 11:30 am
Inflammation, Oxidation and Lung Damage
Brian Day, Ph.D., National Jewish Health, USA
11:30 am – 12:00 pm
Myeloperoxidase Drives Adverse Ventricular Remodeling in Heart Failure by Dysregulating Peripheral Vascular Tone
Stephan Baldus, MD, Cologne University Heart Center, Germany
12:00 pm - 12:30 pm
SfRBM YEAR IN REVIEW: ANNUAL MEMBER MEETING | GRAND BALLROOM A
12:30 pm – 2:30 pm | LUNCH
Attendees on own or attend the professional development session
1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION I | SEACLIFF AB
Developing Business and Entrepreneurial Skills | sponsored by the SFRBM Trainee Council
Natalia Romero, Ph.D., Agilent Technologies and Donald McCarthy, Ph.D., Empire Biotechnologies
Whether you are running your own lab or stepping into a new career in industry, everyone can benefit from developing their business and entrepreneurial skills. In this session, we will discuss basic business etiquette and how it differs in academia and industry. Our panelists will discuss the skills they utilized to become successful in their careers, and provide trainees with advice on how to apply entrepreneurial expertise to best reach their future goals.
1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION II | SEACLIFF CD
Teaching while also Running a Research Program
Karina Ckless, Ph.D., SUNY Pittsburgh, Christine Helms, Ph.D., University of Richmond, and Andres Trostchansky, Ph.D., Universidad de la República - Uruguay
Many of us have a significant teaching commitment, which can compete with time spent leading our research programs and writing grant proposals. Join us for an interactive session, where panelists will share their experience and highlight potential pitfalls and successful strategies in balancing teaching and research, including: course planning, tips for effective teaching, mentoring approaches, laboratory time management, and more.
2:30 pm – 4:15 pm
ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS | GRAND BALLROOMS A, B, C
3 concurrent sessions
4:15 pm – 6:45 pm
FORMAL POSTER PRESENTATIONS | PACIFIC CONCOURSE
6:45 pm – 9:00 pm
OPENING DOORS EVENT | BAYVIEW A
Enhancing your Professional and Personal Management Skills
Organized by Maria Clara Franco, Ph.D., University of Central Florida, Samantha Giordano, Ph.D., University of Alabama at Birmingham, and Michelle Booze, Ph.D., Sanford Health and the Women in Science Committee (WIS)
The event will focus on how to manage personnel, time, money and stress at every stage of a researcher’s career.
9:00 pm – 10:00 pm
HOSPITALITY | GARDEN ROOM
REGISTRATION/INFORMATION DESK
7:00 am - 6:30 pm | Grand Ballroom Foyer
SUNRISE FREE RADICAL SCHOOL
Back to the Basics | 8:00 am – 9:00 am | GRAND BALLROOM A
Chairs: Marcie Cole, Ph.D.., University of Louisville, USA and Madia Trujillo, Ph.D., Universidad de la República - Uruguay, Uruguay
8:00 am – 8:30 am
Redox Biology of the Epigenetic Landscape
Rick Domann, Ph.D., The University of Iowa, USA
8:30 am – 9:00 am
The Origins of Redox Biology
Neil Hogg, Ph.D., Medical College of Wisconsin, USA
PLENARY SESSION 1
9:30 am - 12:00 pm | GRAND BALLROOM A
The Role of Redox Regulation on Epigenetics in Human Diseases
Chairs: Rick Domann, Ph.D., The University of Iowa, USA and Rebecca Oberley-Deegan, Ph.D., University of Nebraska Medical Center, USA
Over the past two decades, epigenetics has started to provide a plausible mechanistic link to explain interactions between the genetic code and others factors such as environment, diet, metabolism and age, all of which play major roles in the development of disease. Loss of epigenetic control and dysregulation of gene expression occurs in a variety of diseases, and as more research has been conducted in this field, it has become apparent that oxidative stress is a major driver of aberrant epigenetic regulation. This plenary session will discuss the role of redox biology and oxidative stress in the development and progression of epigenetic dysregulation in human disease.
9:30 am – 10:00 am
Regulation of the Epigenome by Vitamin C
Gaofeng Wang, Ph.D., University of Miami, USA
10:00 am – 10:30 am
Epigenetic Regulation of SOD3 in Pulmonary Arterial Hypertension
Eva Nozik-Grayck, MD, University of Colorado Denver, USA
10:30 am – 11:00 am | Break
11:00 am – 11:30 am
Epigenetic Regulation of Nrf2 in Cancer
Ah-Ng Tony Kong, Ph.D., Rutgers University, NJ, USA
11:30 am - 12:00 pm
Redox Regulation of Mito-senesence and Dysfunctional Epigenome
Irfan Rahman, Ph.D., University of Rochester Medical Center, USA
PLENARY SESSION 2
9:30 am - 12:00 pm |GRAND BALLROOM B
The Landscape of Reductive Stress
Chairs: Joseph Loscalzo, MD, Ph.D., Harvard Medical School, USA, China and Young-Joon Surh, Ph.D., Seoul National University, South Korea
Redox homeostasis is essential for normal cellular maintenance and physiological functions. Reductive stress (RS), which refers to an abnormal increase of reducing equivalents (e.g. GSH/GSSG, NADH/NAD+, NADPH/NADP+, etc.), is emerging to become recognized as a new frontier in redox field. RS exists in physiological and pathological process, such as aging, cardiomyopathy, diabetes, and Alzheimer's disease. However, much remains unknown about the causative factors, the biological effect and the underlying mechanism, which might impact the future strategy on redox regulation.
9:30 am – 10:00 am
Overview: Reductive Stress of ER and its Function in Aging
Young-Joon Surh, Ph.D., Seoul National University, South Korea
10:00 am – 10:30 am
Adaptive Responses to Reductive Stress in Hypoxia
Joseph Loscalzo, MD, Ph.D., Harvard Medical School, USA
10:30 am – 11:00 am | Break
11:00 am – 11:30 am
Reductive Stress Caused by Sustained Nrf2 Activation: Implications for Its Oncogenic Potential
Young-Joon Surh, Ph.D., Seoul National University, South Korea
11:30 am – 12:00 pm
Reductive Stress: Novel Mechanism for Cardiac Remodeling
Rajasekaran Namakkal-Soorappan, M.Phil., Ph.D., University of Alabama at Birmingham, USA
12:00 pm – 2:30 pm | LUNCH
Attendees on own or attend a professional development session
1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION III | SEACLIFF AB
How to be the Boss – Effectively Managing People and Leading a Productive Research Team
Cristina Maria Furdui, Ph.D., Wake Forest School of Medicine, Nadine Hempel, Ph.D., Penn State College of Medicine, Rajasekaran Namakkal Soorappan, M.Phil., Ph.D., Univ. of Alabama at Birmingham, and Daniel Kim-Shapiro, Ph.D., Wake Forest University
Congratulations, you’re a newly minted principal investigator! Beyond the challenges of obtaining grant funding, you now face the daunting task of developing and running your research laboratory. In this panel discussion, experienced investigators will share their insights on issues such as motivating your team; dealing with “slackers”; personnel conflicts; and effective oversight of research projects including the assignment of roles and responsibilities. Come learn from the successes (and failures) of those who have dealt with the same issues you now face.
1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION IV | SEACLIFF CD
How to Find the Best Lab for Your PhD and Post-Doctoral Work
Janine Santos, Ph.D., NIEHS, NIH, Kris Fritz, Ph.D., University of Colorado Denver, and Roberta Gottlieb, MD, Cedars Sinai
Choosing the right lab for your graduate and post-doctoral studies is a critical step in charting your scientific career. However, with little experience early stage scientists often struggle with these decisions. Senior investigators and post-docs will be on hand to discuss the importance of, and how to find the “right match” for a successful training experience and career development. Topics will address whether or not “pedigree” matters, strategies for networking to identify the right mentor and research area, and the importance of self-assessment.
2:30 pm – 4:15 pm
ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS | GRAND BALLROOMS A, B, C
3 concurrent sessions
4:15 pm – 6:45 pm
FORMAL POSTER PRESENTATIONS | PACIFIC CONCOURSE
6:00 pm – 8:00 pm
FRBM & REDOX BIOLOGY EDITORIAL BOARD MEETINGS & RECEPTION | SEACLIFF A & B
9:00 pm – 10:00 pm
HOSPITALITY | GARDEN ROOM
REGISTRATION/INFORMATION DESK
7:00 am - 7:00 pm | Grand Ballroom Foyer
SUNRISE FREE RADICAL SCHOOL | GRAND BALLROOM
Back to the Basics | 8:00 am – 9:00 am
Chairs: Marcie Cole, Ph.D.., University of Louisville, USA and Madia Trujillo, Ph.D., Universidad de la República - Uruguay, Uruguay
8:00 am – 8:30 am
What is the Oxygen Tension in vivo?
Pedro Cabrales, Ph.D., University of California at San Diego, USA
8:30 am – 9:00 am
The Impact of Hyperoxia in the Developing Lung
Phyllis A. Dennery, MD, Brown University / Rhode Island Hospital, USA
PLENARY SESSION
9:30 am - 12:00 pm | GRAND BALLROOM
Oxygen Matters in Redox Biology
Chairs: Giovanni Mann, Ph.D., King’s College London, UK and Kelvin J. A. Davies, Ph.D., D.Sc., University of Southern California, USA
Alterations in oxygen tension modulate cell function by affecting intracellular NAD(P)H levels, protein kinases, ion channels and endogenous antioxidant defenses. This plenary session aims to provide an up-to-date overview of the critical importance that oxygen tension plays in modulating cell signaling in health and diseases such as cancer and cardiovascular diseases.
9:30 am – 10:00 am
Sleep Apnea, Oxygen Radicals, and Hypertension
Gregg Semenza, MD, Ph.D., Johns Hopkins University School of Medicine, USA
10:00 am – 10:30 am
Nrf2-Keap1 Regulated Redox Signaling Under Physiologica Normoxia
Giovanni Mann, Ph.D., King’s College London, UK
10:30 am – 11:00 am | Break
11:00 am – 11:30 am
Acute Oxygen Sensing Mechanisms
Jose Lopez-Barneo MD, Ph.D., Instituto de Biomedicina de Sevilla (IBiS), University of Seville, Spain
11:30 am - 12:00 pm
Setting the Mood: Regulation of Circuit Function and Behavior by Ambient Oxygen
Mario de Bono, Ph.D., University of Cambridge, UK
12:00 pm – 12:30 pm
SFRRI TREVOR SLATER AWARD | GRAND BALLROOM
Roles of the Oxygen Paradox and Adaptive Homeostasis in the Ageing Phenomenon
Kelvin J.A. Davies, Ph.D., D.Sc., University of Southern California, USA
12:30 pm – 1:00 pm
SFRRI GENERAL ASSEMBLY | GRAND BALLROOM
12:30 pm – 1:00 pm
NEW MEMBER WELCOME MEETING | PLAZA ROOM
1:00 pm – 2:30 pm | LUNCH
Attendees on own or attendee the professional development session
1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION V | SEACLIFF AB
The Manuscript Review Process
Anthony Newman, Elsevier, publisher of Free Radical Biology and Medicine & Redox Biology and Giovanni Mann, Ph.D., King's College London, UK
This interactive session will discuss the peer review process and provide perspectives on how to be a good reviewer.
2:30 pm – 4:15 pm
ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS | GRAND BALLROOM A, B, C
3 concurrent sessions
4:15 pm – 7:00 pm
FORMAL POSTER PRESENTATIONS | PACIFIC CONCOURSE
7:30 pm – 9:30 pm
CLOSING AWARDS BANQUET | GRAND BALLROOM
Featured Speaker
Parker Antin, Ph.D., University of Arizona
FASEB Immediate Past President
9:30 pm - 10:30 pm
HOSPITALITY | GARDEN ROOM
SfRBM/SFRRI 2016 offically adjourns after the Closing Awards Banquet on Saturday, November 19. There will not be a Sunday Plenary Session.
updated 11/17/16
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